methyl 2-amino-2,3-dihydro-1H-indene-2-carboxylate hydrochloride → 2-[4-Methoxy-3-(2-methyl-benzoyl)-benzoylamino]-indane-2-carboxylic acid
Reaction equation
CO[C:3](=[O:21])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[C:6]([C:12](=[O:20])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH3:19])[CH:5]=1.Cl.C[O:24][C:25]([C:27]1([NH2:36])[CH2:35][C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH2:28]1)=[O:26]>>[CH3:11][O:10][C:7]1[CH:8]=[CH:9][C:4]([C:3]([NH:36][C:27]2([C:25]([OH:26])=[O:24])[CH2:28][C:29]3[C:34](=[CH:33][CH:32]=[CH:31][CH:30]=3)[CH2:35]2)=[O:21])=[CH:5][C:6]=1[C:12](=[O:20])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[CH3:19]Participants
3
Procedure
The compound of step 1 was hydrolyzed in analogy to example 2 and the obtained acid reacted with 2-amino-indane-2-carboxylic acid methyl ester hydrochloride in analogy to step 2 of example 13. The obtained ester was hydrolyzed in analogy to example 2.
Sources & evidence
- ORD record
- ord-86c52ae806c443fc922067c1747725c5
- Source dataset
- uspto-grants-2016_05
- Patent number
- US09328071B2
Reaction notes
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