反应详情

2-(3-Hydroxyphenyl)ethanol (400 mg, 2.90 mmol) was dissolved in a mixture of 4 ml of dioxane and 4 ml of water, and sodium hydrogencarbonate (2.43 g, 29 mmol) was added followed by acetic anhydride (2.96 g, 29 mmol) with ice cooling. The mixture was stirred overnight at room temperature and then partitioned between 2 N hydrochloric acid and EA. The aqueous phase was extracted with EA, the combined organic phases were dried over sodium sulfate and evaporated to dryness to yield the crude title compound which was used without further purification.

1. additionwas added
2. custompartitioned between 2 N hydrochloric acid and EA
3. extractionThe aqueous phase was extracted with EA
4. dry with materialthe combined organic phases were dried over sodium sulfate
5. customevaporated to dryness