3-Methylbenzeneethanol → 2-[4-Benzyloxy-3-(2-m-tolyl-ethoxy)-benzoylamino]-indane-2-carboxylic acid methyl ester

HRID 521519Notes

Reaction equation

HRID 521519 reaction equation
C(O[C:4](=[O:20])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:7]([OH:19])[CH:6]=1)C.[C:21]1([CH3:30])[CH:26]=[CH:25][CH:24]=[C:23]([CH2:27][CH2:28]O)[CH:22]=1.[CH3:31][O:32][C:33]([C:35]1([NH2:44])[CH2:43][C:42]2[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH2:36]1)=[O:34]>>[CH3:31][O:32][C:33]([C:35]1([NH:44][C:4](=[O:20])[C:5]2[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)=[C:7]([O:19][CH2:28][CH2:27][C:23]3[CH:22]=[C:21]([CH3:30])[CH:26]=[CH:25][CH:24]=3)[CH:6]=2)[CH2:43][C:42]2[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH2:36]1)=[O:34]

Participants

4

Reactant 3

HCID 746483-MethylbenzeneethanolHCID 11311797HCID 11311797, compoundHCID 45074057Methyl 2-amino-2,3-dihydro-1H-indene-2-carboxylate

Product 1

HCID 670767132-[4-Benzyloxy-3-(2-m-tolyl-ethoxy)-benzoylamino]-indane-2-carboxylic acid methyl ester

Procedure

The compound of step 2 was reacted with 2-m-tolyl-ethanol in analogy to step 1 of example 1, and the obtained ester was hydrolyzed in analogy to example 2. The obtained carboxylic acid was reacted with 2-amino-indane-2-carboxylic acid methyl ester in analogy to step 2 of example 13.

Sources & evidence

ORD record
ord-8e1e52ef7c924a0fb01087fa8399c3a9
Source dataset
uspto-grants-2016_05
Patent number
US09328071B2

Reaction notes

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