HRID521519

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID74648

3-Methylbenzeneethanol

C9H12O

HCID11311797

未命名化合物

HCID45074057

Methyl 2-amino-2,3-dihydro-1H-indene-2-carboxylate

C11H13NO2

PRODUCTS

生成物

结构：COC(=O)C1(NC(=O)c2ccc(OCc3ccccc3)c(OCCc3cccc(C)c3)c2)Cc2ccccc2C1

HCID67076713

未命名化合物

PROCEDURE

实验过程

The compound of step 2 was reacted with 2-m-tolyl-ethanol in analogy to step 1 of example 1, and the obtained ester was hydrolyzed in analogy to example 2. The obtained carboxylic acid was reacted with 2-amino-indane-2-carboxylic acid methyl ester in analogy to step 2 of example 13.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8e1e52ef7c924a0fb01087fa8399c3a9
来源数据集: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09328071B2
来源说明: uspto-grants-2016_05

反应 SMILES

C(O[C:4](=[O:20])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:7]([OH:19])[CH:6]=1)C.[C:21]1([CH3:30])[CH:26]=[CH:25][CH:24]=[C:23]([CH2:27][CH2:28]O)[CH:22]=1.[CH3:31][O:32][C:33]([C:35]1([NH2:44])[CH2:43][C:42]2[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH2:36]1)=[O:34]>>[CH3:31][O:32][C:33]([C:35]1([NH:44][C:4](=[O:20])[C:5]2[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)=[C:7]([O:19][CH2:28][CH2:27][C:23]3[CH:22]=[C:21]([CH3:30])[CH:26]=[CH:25][CH:24]=3)[CH:6]=2)[CH2:43][C:42]2[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH2:36]1)=[O:34]