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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 521519Generated: October 30, 2026

3-Methylbenzeneethanol → 2-[4-Benzyloxy-3-(2-m-tolyl-ethoxy)-benzoylamino]-indane-2-carboxylic acid methyl ester

https://huagongshe.com/reaction/521519

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-MethylbenzeneethanolHCID 74648—
ReactantHCID 11311797HCID 11311797—
ReactantMethyl 2-amino-2,3-dihydro-1H-indene-2-carboxylateHCID 45074057—
Product2-[4-Benzyloxy-3-(2-m-tolyl-ethoxy)-benzoylamino]-indane-2-carboxylic acid methyl esterHCID 67076713—

Reaction Steps

The compound of step 2 was reacted with 2-m-tolyl-ethanol in analogy to step 1 of example 1, and the obtained ester was hydrolyzed in analogy to example 2. The obtained carboxylic acid was reacted with 2-amino-indane-2-carboxylic acid methyl ester in analogy to step 2 of example 13.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09328071B2
Source datasetuspto-grants-2016_05
ORD IDord-8e1e52ef7c924a0fb01087fa8399c3a9
Source noteuspto-grants-2016_05