Lithium Hydroxide → 2-[4-(2-Hydroxy-ethoxy)-3-(2-m-tolyl-ethoxy)-benzoylamino]-indane-2-carboxylic acid

HRID 521523Notes

Reaction equation

HRID 521523 reaction equation
C([O:4][CH2:5][CH2:6][O:7][C:8]1[CH:28]=[CH:27][C:11]([C:12]([NH:14][C:15]2([C:24]([OH:26])=[O:25])[CH2:23][C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:16]2)=[O:13])=[CH:10][C:9]=1[O:29][CH2:30][CH2:31][C:32]1[CH:33]=[C:34]([CH3:38])[CH:35]=[CH:36][CH:37]=1)(=O)C.[OH-].[Li+]>>[OH:4][CH2:5][CH2:6][O:7][C:8]1[CH:28]=[CH:27][C:11]([C:12]([NH:14][C:15]2([C:24]([OH:26])=[O:25])[CH2:23][C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:16]2)=[O:13])=[CH:10][C:9]=1[O:29][CH2:30][CH2:31][C:32]1[CH:33]=[C:34]([CH3:38])[CH:35]=[CH:36][CH:37]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 670763312-[4-(2-Acetoxy-ethoxy)-3-(2-m-tolyl-ethoxy)-benzoylamino]-indane-2-carboxylic acid

Product 1

HCID 670766572-[4-(2-Hydroxy-ethoxy)-3-(2-m-tolyl-ethoxy)-benzoylamino]-indane-2-carboxylic acid

Procedure

The compound of step 1 was hydrolyzed in analogy to example 2 using 6 equivalents lithium hydroxide.

Sources & evidence

ORD record
ord-58909020d2cb4ae8a1079c91d172fd0c
Source dataset
uspto-grants-2016_05
Patent number
US09328071B2

Reaction notes

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