3-Bromo-1,1,1-trifluoro-2-propanone → HCID 118035057, compound

HRID 521692Notes

Reaction equation

HRID 521692 reaction equation
[Br:1][CH2:2][C:3](=[O:8])[C:4]([F:7])([F:6])[F:5].[NH2:9][C:10]1[N:15]=[CH:14][C:13]([Br:16])=[CH:12][N:11]=1>COCCOC>[BrH:1].[Br:16][C:13]1[CH:12]=[N:11][C:10]2[N:15]([CH2:2][C:3]([C:4]([F:7])([F:6])[F:5])([OH:8])[N:9]=2)[CH:14]=1

Participants

4

Reactant 2

HCID 790083-Bromo-1,1,1-trifluoro-2-propanoneHCID 2313102-Amino-5-bromopyrimidine

Product 1

HCID 118035057HCID 118035057, compoundYield 27.9%

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent2×

Procedure

A mixture of 1.91 g of 3-bromo-1,1,1-trifluoropropan-2-one and 5 ml of DME was added to a mixture of 1.74 g of 2-amino-5-bromopyrimidine and 15 ml of DME, and the mixture was stirred at room temperature for 1 day. The precipitated solid was taken by filtration, washed with 10 ml of DME, and dried to obtain 1.02 g of 6-bromo-2-trifluoromethyl-2,3-dihydroimidazo[1,2-a]pyrimidin-2-ol hydrobromide.

Workup

  1. filtrationThe precipitated solid was taken by filtration
  2. washwashed with 10 ml of DME
  3. customdried

Sources & evidence

ORD record
ord-9a7273b95aa647b6aea12b3c49263fea
Source dataset
uspto-grants-2016_05
Patent number
US09328121B1

Reaction notes

Loading…