Hydrochloric Acid → HCID 51001042, compound

HRID 521796Notes

Reaction equation

HRID 521796 reaction equation
[CH3:1][S:2]([CH2:36][CH2:37][CH2:38][C:39]([O:41]C)=[O:40])(=[N:4][C:5]([C:7]1[CH:11]=[C:10]([C:12]2[CH:17]=[C:16]([O:18][C:19]3[CH:24]=[CH:23][C:22]([NH:25][C:26]([NH:28][C:29]4[CH:34]=[CH:33][CH:32]=[C:31]([CH3:35])[CH:30]=4)=[O:27])=[CH:21][CH:20]=3)[CH:15]=[CH:14][N:13]=2)[NH:9][CH:8]=1)=[O:6])=[O:3].[OH-].[Na+].O.Cl>CO>[CH3:1][S:2]([CH2:36][CH2:37][CH2:38][C:39]([OH:41])=[O:40])(=[N:4][C:5]([C:7]1[CH:11]=[C:10]([C:12]2[CH:17]=[C:16]([O:18][C:19]3[CH:24]=[CH:23][C:22]([NH:25][C:26]([NH:28][C:29]4[CH:34]=[CH:33][CH:32]=[C:31]([CH3:35])[CH:30]=4)=[O:27])=[CH:21][CH:20]=3)[CH:15]=[CH:14][N:13]=2)[NH:9][CH:8]=1)=[O:6])=[O:3]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 73669719HCID 73669719, compound

Product 1

HCID 51001042HCID 51001042, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a stirred solution of methyl 4-{S-methyl-N-[(5-{4-[4-({[(3-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrol-3-yl)carbonyl]sulfonimidoyl}butanoate (5 mg, 0.0087 mol) in MeOH (3 ml) was added 1M NaOH (0.5 ml, 0.5 mmol). The mixture was stirred at room temperature for 30 minutes, and poured into 30 ml of water. 2M HCl was added dropwise until pH=4. The precipitates were filtered, washed with water and dried to give 4-{S-methyl-N-[(5-{4-[4-({[(3-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrol-3-yl)carbonyl]sulfonimidoyl}butanoic acid as off-white solid. Yield: 5 mg, 100%.

Workup

  1. filtrationThe precipitates were filtered
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-fa9bf07507d24db3b0b7c676c11effa1
Source dataset
uspto-grants-2016_05
Patent number
US09328103B2

Reaction notes

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