1-(3,5-Difluorophenyl)cyclobutanol → 1-(3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutanol

HRID 521898Notes

Reaction equation

HRID 521898 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:18]([OH:20])[CH3:19])[CH:5]=[C:6]([F:17])[C:7]=1[B:8]1[O:12][C:11]([CH3:14])([CH3:13])[C:10]([CH3:16])([CH3:15])[O:9]1.F[C:22]1C=C(C2(O)CCC2)C=C(F)[CH:27]=1>>[F:17][C:6]1[CH:5]=[C:4]([C:18]2([OH:20])[CH2:27][CH2:22][CH2:19]2)[CH:3]=[C:2]([F:1])[C:7]=1[B:8]1[O:12][C:11]([CH3:13])([CH3:14])[C:10]([CH3:15])([CH3:16])[O:9]1

Participants

3

Reactant 2

HCID 706551711-(3,5-Difluorophenyl)cyclobutanolHCID 867138511-(3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanol

Product 1

HCID 706551101-(3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutanol

Procedure

Following the procedure of Intermediate 106, replacing 1-(3,5-difluorophenyl)ethanol with 1-(3,5-difluorophenyl)cyclobutanol (see US2012/225062) provided the title compound.

Sources & evidence

ORD record
ord-5c128c778c2a40cf99c9cfb9616eacb2
Source dataset
uspto-grants-2016_05
Patent number
US09328106B2

Reaction notes

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