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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 521898Generated: October 30, 2026

1-(3,5-Difluorophenyl)cyclobutanol → 1-(3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutanol

https://huagongshe.com/reaction/521898

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(3,5-Difluorophenyl)cyclobutanolHCID 70655171—
Reactant1-(3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanolHCID 86713851—
Product1-(3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutanolHCID 70655110—

Reaction Steps

Following the procedure of Intermediate 106, replacing 1-(3,5-difluorophenyl)ethanol with 1-(3,5-difluorophenyl)cyclobutanol (see US2012/225062) provided the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09328106B2
Source datasetuspto-grants-2016_05
ORD IDord-5c128c778c2a40cf99c9cfb9616eacb2
Source noteuspto-grants-2016_05