3-Fluoropyridine-4-boronic acid → 2-(3-Fluoropyridin-4-yl)thiazole-4-carboxylic acid

HRID 521902Notes

Reaction equation

HRID 521902 reaction equation
[F:1][C:2]1[CH:7]=C(OC)[CH:5]=[C:4](F)[C:3]=1[C:11]1[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=1.FC1C=[N:22]C=CC=1B(O)O>>[F:1][C:2]1[CH:7]=[N:22][CH:5]=[CH:4][C:3]=1[C:11]1[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=1

Participants

3

Reactant 2

HCID 27793533-Fluoropyridine-4-boronic acidHCID 834100432-(2,6-Difluoro-4-methoxyphenyl)thiazole-4-carboxylic acid

Product 1

HCID 817494242-(3-Fluoropyridin-4-yl)thiazole-4-carboxylic acid

Procedure

Following the procedure of Intermediate 104, replacing 2,6-difluoro-4-methoxyphenylboronic acid with (3-fluoropyridin-4-yl)boronic acid gave the title compound.

Sources & evidence

ORD record
ord-e5be20fd30e944baa9986e59b6a78423
Source dataset
uspto-grants-2016_05
Patent number
US09328106B2

Reaction notes

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