(2,5-Difluorophenyl)boronic acid → 2-(2,5-Difluorophenyl)thiazole-4-carboxylic acid

HRID 521903Notes

Reaction equation

HRID 521903 reaction equation
[F:1][C:2]1[CH:7]=[C:6](OC)[CH:5]=[C:4](F)[C:3]=1[C:11]1[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=1.[F:19]C1C=CC(F)=CC=1B(O)O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:19])=[CH:4][C:3]=1[C:11]1[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=1

Participants

3

Reactant 2

HCID 2734335(2,5-Difluorophenyl)boronic acidHCID 834100432-(2,6-Difluoro-4-methoxyphenyl)thiazole-4-carboxylic acid

Product 1

HCID 636635882-(2,5-Difluorophenyl)thiazole-4-carboxylic acid

Procedure

Following the procedure of Intermediate 104, replacing 2,6-difluoro-4-methoxyphenylboronic acid with (2,5-difluorophenyl)boronic acid gave the title compound.

Sources & evidence

ORD record
ord-1d08c089e14648eb91b770a3cf99863e
Source dataset
uspto-grants-2016_05
Patent number
US09328106B2

Reaction notes

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