2-(2,6-Difluoro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane → 2-(2,6-Difluoro-4-methylphenyl)thiazole-4-carboxylic acid

HRID 521915Notes

Reaction equation

HRID 521915 reaction equation
[F:1][C:2]1[CH:7]=[C:6](OC)[CH:5]=[C:4]([F:10])[C:3]=1[C:11]1[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=1.F[C:20]1C=C(C)C=C(F)C=1B1OC(C)(C)C(C)(C)O1>>[F:1][C:2]1[CH:7]=[C:6]([CH3:20])[CH:5]=[C:4]([F:10])[C:3]=1[C:11]1[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=1

Participants

3

Reactant 2

HCID 666564462-(2,6-Difluoro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane2×HCID 834100432-(2,6-Difluoro-4-methoxyphenyl)thiazole-4-carboxylic acid

Product 1

HCID 867138612-(2,6-Difluoro-4-methylphenyl)thiazole-4-carboxylic acid

Procedure

Following the procedure of Intermediate 104, replacing 2,6-difluoro-4-methoxyphenylboronic acid with 2-(2,6-difluoro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (Intermediate 125) gave the title compound.

Sources & evidence

ORD record
ord-984f96053a544be7838cf515cc074540
Source dataset
uspto-grants-2016_05
Patent number
US09328106B2

Reaction notes

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