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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 521915Generated: October 31, 2026

2-(2,6-Difluoro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane → 2-(2,6-Difluoro-4-methylphenyl)thiazole-4-carboxylic acid

https://huagongshe.com/reaction/521915

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(2,6-Difluoro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneHCID 66656446—
Reactant2-(2,6-Difluoro-4-methoxyphenyl)thiazole-4-carboxylic acidHCID 83410043—
Product2-(2,6-Difluoro-4-methylphenyl)thiazole-4-carboxylic acidHCID 86713861—

Reaction Steps

Following the procedure of Intermediate 104, replacing 2,6-difluoro-4-methoxyphenylboronic acid with 2-(2,6-difluoro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (Intermediate 125) gave the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09328106B2
Source datasetuspto-grants-2016_05
ORD IDord-984f96053a544be7838cf515cc074540
Source noteuspto-grants-2016_05