2-Cyano-6-(trifluoromethyl)pyridine → 2-(6-(Trifluoromethyl)pyridin-2-yl)thiazole-4-carboxylic acid

HRID 521921Notes

Reaction equation

HRID 521921 reaction equation
BrC1C=CC(F)=C(C2[S:9][CH:10]=[C:11]([C:13]([OH:15])=[O:14])N=2)C=1.[F:17][C:18]([F:28])([F:27])[C:19]1[N:24]=[C:23]([C:25]#[N:26])[CH:22]=[CH:21][CH:20]=1>>[F:28][C:18]([F:27])([F:17])[C:19]1[N:24]=[C:23]([C:25]2[S:9][CH:10]=[C:11]([C:13]([OH:15])=[O:14])[N:26]=2)[CH:22]=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 216966182-Cyano-6-(trifluoromethyl)pyridineHCID 826480922-(5-Bromo-2-fluorophenyl)-1,3-thiazole-4-carboxylic acid

Product 1

HCID 867138642-(6-(Trifluoromethyl)pyridin-2-yl)thiazole-4-carboxylic acid

Procedure

Following the procedure of Intermediate 129, replacing 5-bromo-2-fluoro-benzonitrile with 6-(trifluoromethyl)picolinonitrile gave the title compound.

Sources & evidence

ORD record
ord-b4a32331a39f45778ab806e750b176c7
Source dataset
uspto-grants-2016_05
Patent number
US09328106B2

Reaction notes

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