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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 521921Generated: October 31, 2026

2-Cyano-6-(trifluoromethyl)pyridine → 2-(6-(Trifluoromethyl)pyridin-2-yl)thiazole-4-carboxylic acid

https://huagongshe.com/reaction/521921

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Cyano-6-(trifluoromethyl)pyridineHCID 21696618—
Reactant2-(5-Bromo-2-fluorophenyl)-1,3-thiazole-4-carboxylic acidHCID 82648092—
Product2-(6-(Trifluoromethyl)pyridin-2-yl)thiazole-4-carboxylic acidHCID 86713864—

Reaction Steps

Following the procedure of Intermediate 129, replacing 5-bromo-2-fluoro-benzonitrile with 6-(trifluoromethyl)picolinonitrile gave the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09328106B2
Source datasetuspto-grants-2016_05
ORD IDord-b4a32331a39f45778ab806e750b176c7
Source noteuspto-grants-2016_05