2-Fluoro-4-methylbenzonitrile → 2-(2-Fluoro-4-methylphenyl)thiazole-4-carboxylic acid

HRID 521922Notes

Reaction equation

HRID 521922 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([F:16])=[C:6]([C:8]2[S:9][CH:10]=[C:11]([C:13]([OH:15])=[O:14])[N:12]=2)[CH:7]=1.F[C:18]1C=C(C)C=CC=1C#N>>[F:16][C:5]1[CH:4]=[C:3]([CH3:18])[CH:2]=[CH:7][C:6]=1[C:8]1[S:9][CH:10]=[C:11]([C:13]([OH:15])=[O:14])[N:12]=1

Participants

3

Reactant 2

HCID 27784432-Fluoro-4-methylbenzonitrileHCID 826480922-(5-Bromo-2-fluorophenyl)-1,3-thiazole-4-carboxylic acid

Product 1

HCID 623085562-(2-Fluoro-4-methylphenyl)thiazole-4-carboxylic acid

Procedure

Following the procedure of Intermediate 129, replacing 5-bromo-2-fluoro-benzonitrile with 2-fluoro-4-methylbenzonitrile gave the title compound.

Sources & evidence

ORD record
ord-e68348b4c62b4b2586c8f20bceef8714
Source dataset
uspto-grants-2016_05
Patent number
US09328106B2

Reaction notes

Loading…