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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 521922Generated: October 30, 2026

2-Fluoro-4-methylbenzonitrile → 2-(2-Fluoro-4-methylphenyl)thiazole-4-carboxylic acid

https://huagongshe.com/reaction/521922

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Fluoro-4-methylbenzonitrileHCID 2778443—
Reactant2-(5-Bromo-2-fluorophenyl)-1,3-thiazole-4-carboxylic acidHCID 82648092—
Product2-(2-Fluoro-4-methylphenyl)thiazole-4-carboxylic acidHCID 62308556—

Reaction Steps

Following the procedure of Intermediate 129, replacing 5-bromo-2-fluoro-benzonitrile with 2-fluoro-4-methylbenzonitrile gave the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09328106B2
Source datasetuspto-grants-2016_05
ORD IDord-e68348b4c62b4b2586c8f20bceef8714
Source noteuspto-grants-2016_05