HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 52198Generated: October 30, 2026
Potassium Cyanide → (1-Oxo-2,3-dihydro-1H-pyrrolizin-2-yl)acetonitrile
https://huagongshe.com/reaction/52198
Participants
| Role | Name | HCID | Charge |
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| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | 2-Dimethylaminomethyl-1, 2-dihydro-1-pyrrolizinone | HCID 10219668 | — |
| Product | (1-Oxo-2,3-dihydro-1H-pyrrolizin-2-yl)acetonitrile | HCID 54473544 | 68% |
Reaction Steps
To 100 ml H2O0 were added 8.6% of compound 2 and 5.2 g KCN. The solution was gently heated to 100° C. and kept stirring for 10 minutes. After cooling to r.t., the reaction mixture was extracted with CH2CI2 (60×3). Evaporated the solvent, 6 g oil was obtained. Purified by column chromatography on silica gel, 4 g of compound 8 was obtained as white powder, mp 68° C., yield 68%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05616604 |
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| Source dataset | uspto-grants-1997_04 |
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| ORD ID | ord-785f0cdf06ca404cbfc61e979beadff8 |
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| Source note | uspto-grants-1997_04 |
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