反应详情

温度

100 °C

To 100 ml H2O0 were added 8.6% of compound 2 and 5.2 g KCN. The solution was gently heated to 100° C. and kept stirring for 10 minutes. After cooling to r.t., the reaction mixture was extracted with CH2CI2 (60×3). Evaporated the solvent, 6 g oil was obtained. Purified by column chromatography on silica gel, 4 g of compound 8 was obtained as white powder, mp 68° C., yield 68%.

1. temperatureAfter cooling to r.t.
2. extractionthe reaction mixture was extracted with CH2CI2 (60×3)
3. customEvaporated the solvent