反应详情

To 5-(5-bromo-2-chlorobenzamido)-1-phenyl-1H-pyrazole-3-carboxylic acid (Preparation 12, 200 mg, 0.48 mmol), cyclopropylamine (137 mg, 2.40 mmol) and pyridine (114 mg, 1.44 mmol) in methyl THF (5 mL) was added 1-propylphosphonic acid cyclic anhydride (50% solution in EtOAc, 0.48 mL, 0.82 mmol) at room temperature. The reaction was stirred at room temperature for 17 hours. A 2M aqueous solution of potassium carbonate was added until the pH became basic and the solution was extracted with EtOAc (3×15 mL). The combined organic layers were concentrated in vacuo and the residue was purified by silica gel column chromatography eluting with EtOAc to afford the title compound (290 mg, 88%).

1. extractionthe solution was extracted with EtOAc (3×15 mL)
2. concentrationThe combined organic layers were concentrated in vacuo
3. customthe residue was purified by silica gel column chromatography
4. washeluting with EtOAc