HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-2-chlorobenzoic acid → Ethyl 1-(3-(benzyloxy)phenyl)-5-(5-bromo-2-chlorobenzamido)-1H-pyrazole-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-2-chlorobenzoic acid | HCID 33127 | — |
| Reactant | HCID 118497040 | HCID 118497040 | — |
| Product | Ethyl 1-(3-(benzyloxy)phenyl)-5-(5-bromo-2-chlorobenzamido)-1H-pyrazole-3-carboxylate | HCID 118497151 | — |
Reaction Steps
The title compound was prepared according to the method described for Preparation 16 using ethyl 5-amino-1-(3-(benzyloxy)phenyl)-1H-pyrazole-3-carboxylate (Preparation 54) and 2-chloro-5-bromobenzoic acid. The residue was purified using silica gel column chromatography eluting with 30-40% EtOAc in heptanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09328096B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-23e5f4015d374dfba7cf4eb8554d5788 |
| Source note | uspto-grants-2016_05 |