反应详情

温度

80 °C

To a solution of 2,3-dichloro-6-methylpyridine (2 g, 12.3 mmol) in carbon tetrachloride (40 mL) was added NBS (2.64 g, 14.8 mmol) followed by AIBN (40 mg, 0.24 mmol). The reaction heated to 80° C. under nitrogen for 3.5 hours. The reaction was cooled and concentrated in vacuo. The residue was sonicated in heptanes and filtered. The filtrate was eluted through a pad of silica using 10% TBME in heptanes to afford the title compound (2.90 g). The crude material was taken on directly to the next step.

1. temperatureThe reaction was cooled
2. concentrationconcentrated in vacuo
3. customThe residue was sonicated in heptanes
4. filtrationfiltered
5. washThe filtrate was eluted through a pad of silica using 10% TBME in heptanes