Water → HCID 118274259, compound

HRID 522217Notes

Reaction equation

HRID 522217 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:14]([CH3:15])[CH2:13][C:12]3[C:8]4[C:9](=[N:27][CH:28]=[CH:29][C:7]=4[C:6]=2[CH:30]=1)[N:10](S(C1C=CC(C)=CC=1)(=O)=O)[C:11]=3[I:16].[OH-].[Na+].O>O1CCOCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:14]([CH3:15])[CH2:13][C:12]3[C:8]4[C:9](=[N:27][CH:28]=[CH:29][C:7]=4[C:6]=2[CH:30]=1)[NH:10][C:11]=3[I:16]

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 118274112HCID 118274112, compound

Product 1

HCID 118274259HCID 118274259, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
50 °C

Procedure

To a solution of Example 41D (2.0 g, 3.75 mmol) in dioxane (30 mL) was added 1M aqueous sodium hydroxide (15 mL, 15 mmol) and the mixture was stirred at 50° C. overnight. Water was added and the precipitate was filtered, washed with water and hexanes and dried in vacuo to afford the title compound. LC-MS: 380 (M+H)+.

Workup

  1. filtrationthe precipitate was filtered
  2. washwashed with water and hexanes
  3. customdried in vacuo

Sources & evidence

ORD record
ord-511f702bc6f648cb8d40dd08187981f7
Source dataset
uspto-grants-2016_05
Patent number
US09328112B2

Reaction notes

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