Stannous chloride dihydrate → 2,6-dichloro-N4-methylpyrimidine-4,5-diamine

Tin (II) chloride dihydrate (2.0 g) was added to a solution of 2,6-dichloro-N-methyl-5-nitropyrimidine-4-amine (680 mg) in EtOH (13 mL) at room temperature. The mixture was stirred at room temperature for 3 hours, and stirred at 90° C. for 2 hours. The reaction mixture was cooled to room temperature, and concentrated under reduced pressure. EtOAc and a saturated aqueous NaHCO3 solution were added to the residue, and the insoluble material was separated by filtration using Celite. Extraction was performed on the filtrate using EtOAc, and the extract was washed with water and saturated brine. The organic layer was dried over MgSO4 and filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (Hex:EtOAc=80:20 to 50:50), whereby 2,6-dichloro-N4-methylpyrimidine-4,5-diamine (482 mg) was obtained as a pale yellow solid.

1. stirringstirred at 90° C. for 2 hours
2. temperatureThe reaction mixture was cooled to room temperature
3. concentrationconcentrated under reduced pressure
4. additionEtOAc and a saturated aqueous NaHCO3 solution were added to the residue
5. customthe insoluble material was separated by filtration
6. extractionExtraction
7. washthe extract was washed with water and saturated brine
8. dry with materialThe organic layer was dried over MgSO4
9. filtrationfiltered
10. concentrationthe filtrate was concentrated under reduced pressure
11. customThe residue was purified by silica gel column chromatography (Hex:EtOAc=80:20 to 50:50)

ORD record

ord-aef96a59d3d04a2ea150f8f771489af8

Source dataset

uspto-grants-2016_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09328118B2