反应详情

A 4 M solution of hydrogen chloride in dioxane (1 ml) was added to a solution of tert-butyl 4-(2-{4-[7-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-2-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2-(trifluoromethyl)phenoxy}ethyl)piperidine-1-carboxylate (150 mg) in dioxane (1 mL) at room temperature, and the mixture was stirred at the same temperature for 1 hour. After the reaction mixture was concentrated under reduced pressure, the precipitate was washed with diisopropyl ether, and collected by filtration, whereby 7-(2-hydroxyethyl)-4-{4-[2-(piperidin-4-yl)ethoxy]-3-(trifluoromethyl)phenyl}-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile monohydrochloride (110 mg) was obtained as a pale yellow solid.

1. concentrationAfter the reaction mixture was concentrated under reduced pressure
2. washthe precipitate was washed with diisopropyl ether
3. filtrationcollected by filtration