HCID 117599097, compound → ethyl (1R,2S)-1-{[(4S)-4-{[(4-bromophenyl)sulfonyl]oxy}-L-prolyl]amino}-2-ethenylcyclopropanecarboxylate

Participants

Reaction Steps

HCl (4M in dioxane, 300 ml) was added to the product of Step 2 (40 g) and the solution was stirred at room temperature for 30 min. The solvent was evaporated under reduced pressure. The residue was dissolved in ethyl acetate and a saturated sodium bicarbonate solution was added. The phases were separated. The precipitated solid was filtrated from the organic layer to give the desired product (33.8 g) as a white solid. LRMS (ES+) m/z 487.0 (M+H)+.

Provenance & Evidence