反应详情

HCl (4M in dioxane, 300 ml) was added to the product of Step 2 (40 g) and the solution was stirred at room temperature for 30 min. The solvent was evaporated under reduced pressure. The residue was dissolved in ethyl acetate and a saturated sodium bicarbonate solution was added. The phases were separated. The precipitated solid was filtrated from the organic layer to give the desired product (33.8 g) as a white solid. LRMS (ES+) m/z 487.0 (M+H)+.

1. customThe solvent was evaporated under reduced pressure
2. dissolutionThe residue was dissolved in ethyl acetate
3. additiona saturated sodium bicarbonate solution was added
4. customThe phases were separated
5. filtrationThe precipitated solid was filtrated from the organic layer