反应详情

Dimethyl sulfate (0.237 ml) was added to a mixture of 3-(prop-2-en-1-yl)quinoline-2,4-diol (1.0 g) and potassium carbonate (1.37 g) in acetone (100 ml) and the mixture was stirred at room temperature for 3 hours then warmed to 40° C. for 30 minutes. The reaction mixture was cooled and the solids were removed by filtration. The filtrate was concentrated in vacuo. Purification by flash chromatography (ISCO, 4-10% acetone/DCM) gave the desired product (0.70 g). LRMS (ES+) M/Z (M+H)+ 216.0.

1. temperaturethen warmed to 40° C. for 30 minutes
2. temperatureThe reaction mixture was cooled
3. customthe solids were removed by filtration
4. concentrationThe filtrate was concentrated in vacuo
5. customPurification by flash chromatography (ISCO, 4-10% acetone/DCM)