反应详情

To a solution of 2-amino-4-(trifluoromethyl)benzoic acid (5 g) in THF (85 ml) was added diazomethane (48.7 ml) in ether until completion of the reaction. Nitrogen was bubbled into the reaction mixture for 15 minutes to remove the excess of diazomethane and the solvent was removed under reduced pressure to provide a light brown solid (5.34 g). The compound was used in the next without purification. LRMS (ES+) m/z 220.1 (M+H)+.

1. customuntil completion of the reaction
2. customNitrogen was bubbled into the reaction mixture for 15 minutes
3. customto remove the excess of diazomethane
4. customthe solvent was removed under reduced pressure