反应详情

In 30 ml of chloroform was dissolved 0.53 g (1.15 mmol) of 6-trifluoromethylthiohexyl-[2,4-dichloro-5-(2,2,2-trifluoroethylthio)phenyl]ether. Thereto was added 0.26 g (1.13 mmol) of 3-chloroperbenzoic acid (purity: about 75%) at 0° C., and the mixture was stirred for 3 hours at room temperature. Then, the solvent was distilled off under reduced pressure, 0.5 ml of triethylamine was added to the residue, and the residue was purified by silica gel column chromatography (developing solvent: a mixed solvent of n-hexane ethyl acetate=5:1), to obtain 0.41 g (yield: 75%) of an intended product.

1. distillationThen, the solvent was distilled off under reduced pressure, 0.5 ml of triethylamine
2. additionwas added to the residue
3. customthe residue was purified by silica gel column chromatography (