反应详情

To a slurry of Pamoic acid (32.4 g) in ethyl acetate (250 mL) in a clean round bottomed flask, Imipramine (85 g, pre-generated from Imipramine hydrochloride −90 g, sodium hydroxide −18 kg in water, 60-100 mL) solution in ethyl acetate is added maintaining the temperature below 50° C. for 3-4 h. After complete addition, the reaction mixture is stirred at room temperature for about 12-14 h. The bright yellow slurry thus obtained is filtered and washed with ethyl acetate (400 mL) and dried to get Imipramine Pamoate (76 g, 96%) as bright yellow crystalline product.

1. temperaturemaintaining the temperature below 50° C. for 3-4 h
2. additionAfter complete addition
3. customThe bright yellow slurry thus obtained
4. filtrationis filtered
5. washwashed with ethyl acetate (400 mL)
6. customdried