反应详情

To a slurry of Pamoic acid (32.4 g) in ethyl acetate (500 mL) in a clean round bottomed flask, Imipramine (150 g) solution in ethyl acetate is added at such a rate that the temperature remains below 50° C. for 3-4 h. After complete addition, the reaction mixture is stirred at room temperature for about 12-14 h. The bright yellow slurry thus obtained is filtered and washed with ethyl acetate (200 mL) and dried to get Imipramine Pamoate (73 g, 92%) as bright yellow crystalline product.

1. additionAfter complete addition
2. customThe bright yellow slurry thus obtained
3. filtrationis filtered
4. washwashed with ethyl acetate (200 mL)
5. customdried