反应详情

A mixture of 28c (208.6 g, 0.50 mmol) and 104 mg of Pd(OH)2 in 15 mL of methyl alcohol is shaken in a Parr apparatus under hydrogen pressure for 18 h. The reaction mixture is filtered through diatomaceous earth and the filtrate concentrated to give 169 mg of the desired product 25c as an oil. NMR δ0.84 (s, 9H), 1.05 (d, 3H), 1.60 (m, 2.10 (t, 3.31 (m, 6.47 (br d, 1H).

1. filtrationThe reaction mixture is filtered through diatomaceous earth
2. concentrationthe filtrate concentrated