反应详情

(R)-3-(N-Isopropylamino)-5-methoxy-3,4-dihydro-2H-1-benzopyran (4.02 g, 18.2 mmol) and anhydrous sodium acetate were dissolved in acetic acid (80 mL). To the stirred mixture was bromine (0.93 mL, 18.2 mmol) dissolved in acetic acid (40 mL) added dropwise under 1.5 h. The solvent was removed in vacuo, taken into a 2M NaOH solution and extracted twice with diethyl ether. The combined ether portions were treated with brine, dried (Na2SO4), filtered, and the solvent was removed in vacuo to give the crude residue. The hydrochloride salt was made by dissolving the pure base in diethyl ether and adding an excess of an ethereal HCl solution to give a white solid. The salt was recrystallized twice from ethanol/diethyl ether to give 3.8 g (62% yield) Mp: 257°-8° C. [α]21D =-97.7° (C=0.1 CHCl3). The free base was made from the hydrochloride salt to give an oil. GC-MS (70 eV) M=301 (100%).

1. additionadded dropwise under 1.5 h
2. customThe solvent was removed in vacuo
3. extractionextracted twice with diethyl ether
4. additionThe combined ether portions were treated with brine
5. dry with materialdried (Na2SO4)
6. filtrationfiltered
7. customthe solvent was removed in vacuo
8. customto give the crude residue
9. customto give a white solid
10. customThe salt was recrystallized twice from ethanol/diethyl ether
11. customto give 3.8 g (62% yield) Mp: 257°-8° C. [α]21D =-97.7° (C=0.1 CHCl3)
12. customto give an oil