1,4-Dioxane hydrochloride → 5-(2-Fluorophenoxy)-2-(1-piperazinyl)pyrimidine hydrochloride

HRID 522657Notes

Reaction equation

HRID 522657 reaction equation
[F:1][C:2]1[CH:27]=[CH:26][CH:25]=[CH:24][C:3]=1[O:4][C:5]1[CH:6]=[N:7][C:8]([N:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]2)=[N:9][CH:10]=1.[ClH:28].O1CCOCC1>O1CCOCC1>[ClH:28].[F:1][C:2]1[CH:27]=[CH:26][CH:25]=[CH:24][C:3]=1[O:4][C:5]1[CH:6]=[N:7][C:8]([N:11]2[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]2)=[N:9][CH:10]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 118022170Tert-butyl 4-(5-(2-fluorophenoxyl)pyrimidin-2-yl)piperazine-1-carboxylate

Product 1

HCID 1180226885-(2-Fluorophenoxy)-2-(1-piperazinyl)pyrimidine hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of tert-butyl 4-(5-(2-fluorophenoxyl)pyrimidin-2-yl)piperazine-1-carboxylate (50 mg, 0.13 mmol) in dioxane (3 mL) was added 4 M HCl/dioxane (3 mL). The reaction mixture was stirred at room temperature overnight and then concentrated to dryness. The residue (50 mg, yellow solid) was directly used in the next reaction.

Workup

  1. concentrationconcentrated to dryness
  2. customThe residue (50 mg, yellow solid) was directly used in the next reaction

Sources & evidence

ORD record
ord-15afa9800da44b26bd08a285014c6706
Source dataset
uspto-grants-2016_05
Patent number
US09334263B2

Reaction notes

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