1,4-Dioxane hydrochloride → 5-(2-Fluorophenoxy)-2-(1-piperazinyl)pyrimidine hydrochloride

Participants

Reaction Steps

To a solution of tert-butyl 4-(5-(2-fluorophenoxyl)pyrimidin-2-yl)piperazine-1-carboxylate (50 mg, 0.13 mmol) in dioxane (3 mL) was added 4 M HCl/dioxane (3 mL). The reaction mixture was stirred at room temperature overnight and then concentrated to dryness. The residue (50 mg, yellow solid) was directly used in the next reaction.

Provenance & Evidence