1,4-Dioxane hydrochloride → 5-(1-Phenylcyclopropyl)-2-(piperazin-1-yl)pyrimidin

HRID 522694Notes

Reaction equation

HRID 522694 reaction equation
[C:1]1([C:7]2([C:10]3[CH:11]=[N:12][C:13]([N:16]4[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]4)=[N:14][CH:15]=3)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.O1CCOCC1>O1CCOCC1>[C:1]1([C:7]2([C:10]3[CH:15]=[N:14][C:13]([N:16]4[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]4)=[N:12][CH:11]=3)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 118023385Tert-butyl 4-(5-(1-phenylcyclopropyl)pyrimidin-2-yl)piperazine-1-carboxylate

Product 1

HCID 1180230165-(1-Phenylcyclopropyl)-2-(piperazin-1-yl)pyrimidin

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of tert-butyl 4-(5-(1-phenylcyclopropyl)pyrimidin-2-yl)piperazine-1-carboxylate (30 mg, 0.08 mmol) in dioxane (2 mL) was added 4 M HCl-dioxane (2 mL). The reaction mixture was stirred at room temperature overnight and then concentrated to afford crude 5-(1-phenylcyclopropyl)-2-(piperazin-1-yl)pyrimidin. MS (ES+) C17H20N4 requires: 280, found: 281 [M+H]+.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-225300bc2fef474fbc3d813b86873d20
Source dataset
uspto-grants-2016_05
Patent number
US09334263B2

Reaction notes

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