HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane hydrochloride → 5-(1-Phenylcyclopropyl)-2-(piperazin-1-yl)pyrimidin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | Tert-butyl 4-(5-(1-phenylcyclopropyl)pyrimidin-2-yl)piperazine-1-carboxylate | HCID 118023385 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-(1-Phenylcyclopropyl)-2-(piperazin-1-yl)pyrimidin | HCID 118023016 | — |
Reaction Steps
To a solution of tert-butyl 4-(5-(1-phenylcyclopropyl)pyrimidin-2-yl)piperazine-1-carboxylate (30 mg, 0.08 mmol) in dioxane (2 mL) was added 4 M HCl-dioxane (2 mL). The reaction mixture was stirred at room temperature overnight and then concentrated to afford crude 5-(1-phenylcyclopropyl)-2-(piperazin-1-yl)pyrimidin. MS (ES+) C17H20N4 requires: 280, found: 281 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09334263B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-225300bc2fef474fbc3d813b86873d20 |
| Source note | uspto-grants-2016_05 |