反应详情

Sodium hydroxide solution (1 N, 3.51 ml) was added to methyl 2-(ethoxymethyl)-1-(2-hydroxy-2-methylpropyl)-4-(tritylamino)-1H-imidazo[4,5-c]quinoline-7-carboxylate (540 mg, 878 μmol) dissolved in THF (6.21 mL) and methanol (621 μL). The reaction mixture was stirred for 120 hours at room temperature and concentrated in vacuo. The residue was partitioned between ethyl acetate (30 mL) and cold 1M HCl solution (5 mL). The aqueous layer was extracted with ethyl acetate (2×50 mL). Organic layers were washed with water (20 mL) and brine (20 mL), combined, dried with MgSO4, and concentrated in vacuo to obtain the title compound (0.499 g, 94%) as white solid; LC-MS (UV peak area, ESI) 99%, 601.3 (MH+).

1. concentrationconcentrated in vacuo
2. customThe residue was partitioned between ethyl acetate (30 mL) and cold 1M HCl solution (5 mL)
3. extractionThe aqueous layer was extracted with ethyl acetate (2×50 mL)
4. washOrganic layers were washed with water (20 mL) and brine (20 mL)
5. dry with materialdried with MgSO4
6. concentrationconcentrated in vacuo