反应详情

To 4-(2-methanesulfonyl-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester (2.6 g, 7.3 mmol) was added HCl in dioxane solution (4M) (15 mL). The reaction mixture was stirred at RT for 5 h. After completion of the reaction (monitored by TLC), the excess dioxane was removed in vacuo affording an off white solid. The crude material was washed with diethyl ether (3×20 mL) to afford 4-(2-(methylsulfonyl)phenoxy)piperidine hydrochloride (1.3 g, 80.7%).

1. customAfter completion of the reaction (monitored by TLC)
2. customthe excess dioxane was removed in vacuo
3. customaffording an off white solid
4. washThe crude material was washed with diethyl ether (3×20 mL)