Trifluoroacetic acid → HCID 86685243, compound

Participants

Reaction Steps

5-(2,2,2-Trifluoroethoxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate (120 mg) was dissolved in DCM (6 mL) followed by addition of TFA (2 mL). The reaction mixture was stirred at RT for 20 min. The reaction solvent was removed under reduced pressure and the residue was dried on high vacuum overnight to yield 5-(2,2,2-trifluoroethoxy)-1,2,3,4-tetrahydroisoquinoline 2,2,2-trifluoroacetate (125 mg) as a colorless oil which was used without purification.

Provenance & Evidence