Trifluoroacetic acid → HCID 86685243, compound

HRID 522882Notes

Reaction equation

HRID 522882 reaction equation
[F:1][C:2]([F:19])([F:18])[CH2:3][O:4][C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH2:7][CH2:8][N:9](C([O-])=O)[CH2:10]2.[C:20]([OH:26])([C:22]([F:25])([F:24])[F:23])=[O:21]>C(Cl)Cl>[F:23][C:22]([F:25])([F:24])[C:20]([OH:26])=[O:21].[F:19][C:2]([F:1])([F:18])[CH2:3][O:4][C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH2:7][CH2:8][NH:9][CH2:10]2

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86685245HCID 86685245, compound

Product 1

HCID 86685243HCID 86685243, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

5-(2,2,2-Trifluoroethoxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate (120 mg) was dissolved in DCM (6 mL) followed by addition of TFA (2 mL). The reaction mixture was stirred at RT for 20 min. The reaction solvent was removed under reduced pressure and the residue was dried on high vacuum overnight to yield 5-(2,2,2-trifluoroethoxy)-1,2,3,4-tetrahydroisoquinoline 2,2,2-trifluoroacetate (125 mg) as a colorless oil which was used without purification.

Workup

  1. customThe reaction solvent was removed under reduced pressure
  2. customthe residue was dried on high vacuum overnight

Sources & evidence

ORD record
ord-d2696a7603074ef5bbfcab930954250a
Source dataset
uspto-grants-2016_05
Patent number
US09334269B2

Reaction notes

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