HRID523002

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10796

Cesium carbonate

CCs2O3

结构：CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21

HCID636044

1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)

C39H32OP2

HCID22391981

3-Bromo-5-(methanesulfonyl)pyridine

C6H6BrNO2S

结构：CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(N)nc12

HCID90041356

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(Nc3cncc(S(C)(=O)=O)c3)nc12

HCID90041605

未命名化合物

收率 95.3%

AUXILIARIES

试剂、催化剂与溶剂

结构：O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Pd].[Pd]

催化剂HCID9811564

Bis(dibenzylideneacetone)palladium

C51H42O3Pd2

溶剂HCID31275

1,4-Dioxane

C4H8O2

CONDITIONS

反应条件

温度: 150 °C

PROCEDURE

实验过程

To a mixture of 2-amino-N-tert-butyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (92 mg, 253 mol), 3-bromo-5-(methylsulfonyl)pyridine (77.7 mg, 329 mol), xantphos (43.9 mg, 75.9 mol), Pd2(dba)3 (23.2 mg, 25.3 mol) and cesium carbonate (165 mg, 506 mol) in dioxane (2 mL) was heated in a microwave at 150° C. for 20 min. The mixture was cooled then filtered through a pad of celite. The filtrate was concentrated in vacuo then purified by chromatography (silica, 30-70% ethyl acetate in hexanes) to give N-tert-butyl-2-(5-(methylsulfonyl)pyridin-3-ylamino)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (125 mg, 241 mol, 95%) as a yellow gum. (EI/CI) m/z: 519.3 [M+H].

WORKUP

后处理

temperatureThe mixture was cooled
filtrationthen filtered through a pad of celite
concentrationThe filtrate was concentrated in vacuo
customthen purified by chromatography (silica, 30-70% ethyl acetate in hexanes)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ac371b25a4a3452aaf94fa2389b61fdf
来源数据集: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09334278B2
来源说明: uspto-grants-2016_05

反应 SMILES

[NH2:1][C:2]1[N:3]=[C:4]2[C:10]([C:11]([NH:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])=[CH:9][N:8]([CH2:18][O:19][CH2:20][CH2:21][Si:22]([CH3:25])([CH3:24])[CH3:23])[C:5]2=[N:6][CH:7]=1.Br[C:27]1[CH:28]=[N:29][CH:30]=[C:31]([S:33]([CH3:36])(=[O:35])=[O:34])[CH:32]=1.CC1(C)C2C(=C(P(C3C=CC=CC=3)C3C=CC=CC=3)C=CC=2)OC2C(P(C3C=CC=CC=3)C3C=CC=CC=3)=CC=CC1=2.C(=O)([O-])[O-].[Cs+].[Cs+]>O1CCOCC1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[C:14]([NH:13][C:11]([C:10]1[C:4]2[C:5](=[N:6][CH:7]=[C:2]([NH:1][C:27]3[CH:28]=[N:29][CH:30]=[C:31]([S:33]([CH3:36])(=[O:35])=[O:34])[CH:32]=3)[N:3]=2)[N:8]([CH2:18][O:19][CH2:20][CH2:21][Si:22]([CH3:25])([CH3:24])[CH3:23])[CH:9]=1)=[O:12])([CH3:15])([CH3:16])[CH3:17]