HCID 89995591, compound → HCID 89995631, compound

HRID 523088Notes

Reaction equation

HRID 523088 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:13]([N:15]2[CH2:18][CH:17]([O:19][CH3:20])[CH2:16]2)=[O:14])[CH:7]=[CH:8][C:9]=1[N+:10]([O-])=O)[CH3:2]>C(OCC)(=O)C.[Pd]>[NH2:10][C:9]1[CH:8]=[CH:7][C:6]([C:13]([N:15]2[CH2:18][CH:17]([O:19][CH3:20])[CH2:16]2)=[O:14])=[CH:5][C:4]=1[O:3][CH2:1][CH3:2]

Participants

4

Reactant 1

HCID 89995591HCID 89995591, compound

Product 1

HCID 89995631HCID 89995631, compoundYield 98.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A solution of (3-ethoxy-4-nitrophenyl)(3-methoxyazetidin-1-yl)methanone (Preparation 113, 230 mg, 0.821 mmol) in ethyl acetate (10 mL) was stirred with 10% palladium on charcoal under an atmosphere of hydrogen gas for 1 hour. The reaction mixture was filtered through a pad of celite, the filtrate collected and concentrated in vacuo to afford the title compound as a white solid (202 mg, 98%).

Workup

  1. filtrationThe reaction mixture was filtered through a pad of celite
  2. customthe filtrate collected
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-160143388afe43938b1c9c83008256c9
Source dataset
uspto-grants-2016_05
Patent number
US09334286B2

Reaction notes

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