Hydrogen Peroxide → HCID 86638322, compound

HRID 523129Notes

Reaction equation

HRID 523129 reaction equation
[CH2:1]([O:3][P:4]([C:9]([C:12]1[CH:21]=[C:20]2[C:15]([CH:16]=[CH:17][C:18]([CH:22]=[O:23])=[N:19]2)=[CH:14][C:13]=1[Br:24])([F:11])[F:10])(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2].[OH:25]O>C(O)=O>[Br:24][C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][C:12]=1[C:9]([P:4]([O:5][CH2:6][CH3:7])([O:3][CH2:1][CH3:2])=[O:8])([F:10])[F:11])[N:19]=[C:18]([C:22]([OH:25])=[O:23])[CH:17]=[CH:16]2

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 86638323HCID 86638323, compound

Product 1

HCID 86638322HCID 86638322, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

As described in the literature (Synthesis, 1993, 295), to the product of step 4 (105 mg, 0.25 mmol) in 1 ml formic acid was added 30% hydrogen peroxide (0.13 mL, 1 mmol) dropwise and the mixture was stirred overnight at rt. The solvent was evaporated and absolute ethanol was added. This was repeated 3 times and after evaporation of the remaining ethanol yielded the title product as an oil.

Workup

  1. customThe solvent was evaporated
  2. additionabsolute ethanol was added
  3. customafter evaporation of the remaining ethanol

Sources & evidence

ORD record
ord-83702fad13d44bb7b0482a9ebb1965cf
Source dataset
uspto-grants-2016_05
Patent number
US09334295B2

Reaction notes

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