反应详情

4.0 g (10.7 mmol) 2,2-bis(4-nitrobenzyl)malonic acid are dissolved in 40 ml THF and added dropwise at the course of 2 hours to 64.1 ml (64.1 mmol) of a borane-tetrahydrofuran complex 1.0 M solution in THF, which is used without further purification. After 19 hours at 25° C., 50 ml of water are carefully added. The reaction mixture is then partitioned between ethyl acetate and water. The organic phase is washed repeatedly with water, dried over sodium sulfate, filtered and concentrated by rotary evaporation to give 3.8 g of 2,2-bis(4-nitrobenzyl)-1,3-propandiol as a white powder.

1. customwhich is used without further purification
2. addition50 ml of water are carefully added
3. customThe reaction mixture is then partitioned between ethyl acetate and water
4. washThe organic phase is washed repeatedly with water
5. dry with materialdried over sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated by rotary evaporation