反应详情

To a 200 mL round bottom flask were added 10 g (70 mmol) of methyl 3-thiophenecarboxylate, 17 g (79 mmol) of 1-tetradecanol, 1 mL methanesulfonic acid, and 50 mL of toluene. This mixture was heated to reflux for 17 hours. After the solvent was removed, the remaining methyl 3-thiophenecarboxylate was removed by kugelrohr distillation. The remaining residue was filtered through a silica gel pad with 10% ethyl acetate in hexane. The solvents were removed from the filtrate to provide 21 g of the desired compound. The NMR data were obtained and were consistent with those of the desired compound.

1. temperatureThis mixture was heated
2. temperatureto reflux for 17 hours
3. customAfter the solvent was removed
4. customthe remaining methyl 3-thiophenecarboxylate was removed by kugelrohr distillation
5. filtrationThe remaining residue was filtered through a silica gel pad with 10% ethyl acetate in hexane
6. customThe solvents were removed from the filtrate