反应详情

A mixture of the intermediate 5-b (167 g, 932 mmol) in ethanol (1400 mL) was hydrogenated (50 Psi) at 20° C. with wet 10% Pd/C (34 g) as a catalyst overnight. After uptake of H2 (3 eq.), the catalyst was filtered off and the filtrate was evaporated. The residue was washed with MTBE to afford compound 5-c as a yellow powder (133 g, 95%).

1. customat 20° C.
2. customovernight
3. filtrationAfter uptake of H2 (3 eq.), the catalyst was filtered off
4. customthe filtrate was evaporated
5. washThe residue was washed with MTBE