HuagongsheHuagongshe Chemistry Print Report · For research reference only
D-Psicose → 4-N-cyclopropylpyridine-3,4-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | D-Psicose | HCID 441036 | — |
| Reactant | N-Cyclopropyl-3-nitropyridin-4-amine | HCID 22349359 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-N-cyclopropylpyridine-3,4-diamine | HCID 19102553 | 95.7% |
Reaction Steps
A mixture of the intermediate 5-b (167 g, 932 mmol) in ethanol (1400 mL) was hydrogenated (50 Psi) at 20° C. with wet 10% Pd/C (34 g) as a catalyst overnight. After uptake of H2 (3 eq.), the catalyst was filtered off and the filtrate was evaporated. The residue was washed with MTBE to afford compound 5-c as a yellow powder (133 g, 95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09339494B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-67d0495ab47c478b95b9b35b912050c1 |
| Source note | uspto-grants-2016_05 |