反应详情

温度

10 °C

CDI (CAS 530-62-1) (151.8 g, 936 mmol) was added to a solution of the intermediate 5-c (133 g, 891.4 mmol) in CH3CN (1800 mL) at 0° C. The reaction was allowed to warm to 10° C. and stirred for 1 hour. The solid was collected by filtration, then washed with CH3CN (200 mL) to afford compound 5-d as a white powder (101 g, 65%).

1. filtrationThe solid was collected by filtration
2. washwashed with CH3CN (200 mL)
3. customto afford compound 5-d as a white powder (101 g, 65%)